Shenzhen Advanced Institute and others published a review of the progress of the application of shape-adapted biological devices in the field of wearable and implantation

Recently, a team of researchers from Du Xuemin, NanoRegulation Center of Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, together with Professor Anderson Ho Cheung Shum from the University of Hong Kong, published a review of the research progress of shape-adapted biological devices in Lab on a Chip (Impact Factor: 6.77), and was selected as the cover of the current period. This review summarizes the research progress of shape-adapted biological devices for the complex curvature surface of human tissues, details the design strategies, control methods, and innovative applications in intelligent fabric, wound care, health monitoring, drug delivery, tissue regeneration, nerve stimulation, biopsy sampling, minimally invasive surgery, and summarizes the existing challenges and future directions of shape-adapted biological devices (Lab on a Chip, 2020,20,4321-4341.).

　　The rapid development of wearable and implantable biological devices has brought many revolutionary advances to disease diagnosis and treatment. However, wearable and implantable biological devices in planar or simple curved form generally mismatch with human tissues with complex curvature, which greatly affects the performance of the device and the diagnosis and treatment effect. In recent years, based on the on-demand deformation materials of biological devices can actively adapt to the different human tissue surface of complex curvature, significantly improved the wearable and implantable biological devices and the shape of human tissue mismatch at the same time, also has the function of minimally invasive implantation, which greatly enhances the biological devices in the application prospect in the field of different disease diagnosis and treatment.

　　In the previous research work, Du Xuemin's research team specializes in the construction and shape regulation strategies of shape-adapted biological devices (Adv. Mater. 2017, 29, 1702231; Research, 2019, 2019, 6398296; Adv. Funct. Mater.,2020, 30, 1909202) and shape-adapted biological devices in the wearable (J. Mater. Chem. B, 2020, 8,3519; Matter, 2019, 1,626; Materials Horizons, 2020, 7,1341), and the implant (Nat l. Sci. Rev., 2020, 7,629; Adv. Funct. Mater.,2018, 28, 1801027; Adv. Mater. Technol.,2019, 4,1900566; Adv. Mater. Technol.,2017, 2,1700120; Microsystems & Nanoengineering, 2020, 6,58) Important progress has been made in innovative applications and other areas. Based on the above studies and the representative work in this field, this review systematically summarizes the rapid development of shape-adapted biological devices for the disease diagnosis and treatment, discusses the existing challenges in physiological environment response sensitivity, shape regulation accuracy and reliability, and discusses the next generation of intelligent biological devices with the ability to perceive complex physiological environment and can realize from active shape adaptation to active function adaptation. 　  

　The authors are associate professor Qilong Zhao, and the corresponding authors are Professor Xuemin Du and Professor Anderson Ho Cheung Shum. This series of research work has been funded by the National Key RESEARCH and Development Program, the National Natural Science Foundation of China, the Youth Innovation Promotion Association of the Chinese Academy of Sciences, Guangdong Province, Shenzhen city and other science and technology projects.

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Shape-adapted biological devices: applications in the field of wearable and implantation